2-Bromo-4'-methylacetophenone → HCID 86672938, compound

Participants

Reaction Steps

Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (95 mg, 0.27 mmol, prepared as in example 4) and 2-bromo-1-p-tolylethanone (62.3 mg, 0.29 mmol) were dissolved in acetonitrile (10 ml) and stirred at room temperature overnight. The solvent was evaporated, and the residue was triturated with Et2O/EtOAc (1/1) and recovered by suction filtration to obtain 3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-oxo-2-p-tolylethyl)-1-azoniabicyclo[2.2.2]octane bromide (117.6 mg, racemic mixture).

Provenance & Evidence