反应详情

Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (86 mg, 0.24 mmol, prepared as in example 4) and ethyl 5-(2-bromoacetyl)isoxazole-3-carboxylate (69.4 mg, 0.26 mmol) were dissolved in acetonitrile (3 ml) and stirred at room temperature overnight. The precipitated was recovered by suction filtration to obtain 3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-(3-(ethoxycarbonyl)isoxazol-5-yl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide (26 mg, racemic mixture).

1. filtrationThe precipitated was recovered by suction filtration