2-Bromo-2'-fluoroacetophenone → HCID 70673754, compound

Participants

Reaction Steps

Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (90 mg, 0.25 mmol, prepared as in example 4) and 2-bromo-1-(2-fluorophenyl)ethanone (65.6 mg, 0.30 mmol) were dissolved in acetonitrile (4 ml) and stirred at room temperature overnight. Acetonitrile was evaporated, and the residue was triturated with Et2O and filtered to obtain 3-((bis(3-fluorophenyl)methoxy)-carbonyl)-1-(2-(2-fluorophenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide (51.3 mg, racemic mixture).

Provenance & Evidence