Benzyl Bromide → HCID 86672942, compound

Participants

Reaction Steps

To a solution of bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (90 mg, 0.25 mmol, prepared as in example 4) in EtOAc (3 ml), (bromomethyl)benzene (30.0 μl, 0.25 mmol) was added, and the reaction was stirred at room temperature overnight. The solvent was removed, and the crude was purified by flash chromatography (DCM/MeOH=95/5) to obtain 1-benzyl-3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-azoniabicyclo[2.2.2]octane bromide (50 mg, racemic mixture).

Provenance & Evidence