Hydrochloric Acid → 1,2,3,4-Tetrahydro-2-methyl-N-(2-(methylsulfonyl)-5-(piperazin-1-yl)phenyl)naphthalen-1-amine hydrochloride

Participants

Reaction Steps

A solution of 1,2,3,4-tetrahydro-2-methyl-N-(2-(methylsulfonyl)-5-(piperazin-1-yl)phenyl)naphthalen-1-amine (70.0 mg, 0.18 mmol) in anhydrous dichloromethane (1.0 mL) was cooled to 0° C. and HCl (96 μL of a 1M solution in diethyl ether, 0.19 mmol) were added. The mixture was allowed to stir for 10 min. After removal of solvent by rotary evaporation the desired product was collected (82.0 mg, 100%). 1H NMR (400 MHz, CD3OD): δ 7.58 (d, 1H), 7.25 (t, 1H), 7.15 (m, 3H), 6.41 (d, 1H), 6.27 (s, 1H), 4.45 (d, 1H), 3.47 (m, 4H), 3.36 (m, 1H), 3.30 (m, 4H), 2.98 (s, 3H), 2.30 (m, 1H), 2.08 (m, 2H), 1.72 (m, 1H), 1.13 (d, 3H); MS (ESI) m/z: 400.2 (M++1).

Provenance & Evidence