反应详情

温度

110 °C

A mixture of 200 mg (0.604 mmol) N-{2-(2-cyano-3-oxobut-1-en-1-yl)furo[3,2-c]pyridin-4-yl}benzamide (Example 4A) and 129 mg (0.724 mmol) 3-amino-3-(4-chlorophenyl)prop-2-enenitrile (Example 6A) in acetic acid (2 ml) was stirred for 30 min at 110° C. Upon cooling, the mixture was concentrated under reduced pressure, and the residue was directly purified by preparative RP-HPLC (acetonitrile/water+0.1% TFA gradient, final mixture 90:10 v/v) to yield 197 mg (64% of th.) of the racemic title compound.

1. temperatureUpon cooling
2. concentrationthe mixture was concentrated under reduced pressure
3. customthe residue was directly purified by preparative RP-HPLC (acetonitrile/water+0.1% TFA gradient, final mixture 90:10 v/v)