反应详情

温度

110 °C

A mixture of 69 mg (0.260 mmol) N-(2-formylfuro[3,2-c]pyridin-4-yl)benzamide (Example 3A) and 43 mg (0.52 mmol) (2Z)-3-aminobut-2-enenitrile in acetic acid (4.5 ml) was stirred for 45 min at 110° C. Upon cooling, the reaction mixture was concentrated under reduced pressure, and the residue was treated with ethyl acetate and saturated aq. sodium carbonate solution. The organic layer was separated, washed with brine and water, dried over sodium sulfate, and concentrated under reduced pressure to afford the title compound (45 mg, 43% of th.) as a pale yellow solid.

1. temperatureUpon cooling
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionthe residue was treated with ethyl acetate and saturated aq. sodium carbonate solution
4. customThe organic layer was separated
5. washwashed with brine and water
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated under reduced pressure