5-Amino-3-methylisoxazole → HCID 135980549, compound

Participants

Reaction Steps

A mixture of 200 mg (0.604 mmol) N-{2-(2-cyano-3-oxobut-1-en-1-yl)furo[3,2-c]pyridin-4-yl}benzamide (Example 4A), 59 mg (0.604 mmol) 3-methyl-1,2-oxazol-5-amine and a trace amount of powdered 4 Å molecular sieve in 2-propanol (2 ml) was stirred at 90° C. for 12 h. Upon cooling, the mixture was concentrated under reduced pressure, and the residue was directly purified by preparative RP-HPLC (methanol/water+0.1% TFA gradient, final mixture 100% methanol) to yield 64 mg (26% of th.) of the racemic title compound.

Provenance & Evidence