HCID 67471938, compound → HCID 67283814, compound

Participants

Reaction Steps

tert-Butyl 6-(7-chloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine-1-carboxylate (308 mg) was dissolved in 4 N HCl in dioxane (20 mL) and it was held at room temperature for an hour, then partitioned between aqueous sodium bicarbonate and EtOAc. The organic fraction was washed with brine, then dried over sodium sulfate, then concentrated and used further without purification (250 mg, 95% yield). 1H-NMR (300 MHz, CDCl3) δ 8.60 (bs, 1H), 8.10 (s, 1H), 7.80-7.10 (m, 14H), 6.90 (d, 2H), 6.62 (d, 2H), 5.65 (d, 1H), 4.55 (d, 1H), 3.95 (m, 1H), 3.80-3.60 (m, 8H), 1.60 (bs, 2H).

Provenance & Evidence