Benzamide → HCID 58514167, compound

HRID 1910738Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[C:10]([C:14](=[O:23])[CH2:15]CN3CCOCC3)[CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1.[C:24](N)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:14]([C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:1][C:24](=[O:31])[C:25]3[CH:30]=[CH:29][C:28]([C:6]([CH3:8])([CH3:7])[CH3:5])=[CH:27][CH:26]=3)[CH:7]=2)[CH:13]=[CH:12][CH:11]=1)(=[O:23])[CH3:15]

Participants

Reactant 2

HCID 2331Benzamide

HCID 58514251HCID 58514251, compound

Product 1

HCID 58514167HCID 58514167, compound

Procedure

According to the same procedure for the preparation of 1-[3-(2-Amino-pyridin-4-yl)-phenyl]-3-morpholin-4-yl-propan-1-one, 4-tert-Butyl-N-{4-3-(3-morpholin-4-yl-propionyl)-phenyl]-pyridin-2-yl}-benzamide (12 mg, 30%) was obtained from N-[4-(3-Acetyl-phenyl)-pyridin-2-yl]-4-tert-butyl-benzamide (36 mg, 0.1 mmol). MS: m/z 472.3 [MH+].

Sources & evidence

ORD record: ord-84378d46a5dc40698bee23a3f743bbab
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08604031B2

Reaction notes

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