HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → HCID 24998228, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 86639584 | HCID 86639584 | — |
| Catalyst | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| Solvent | Dimethylformamide toluene | HCID 21735183 | — |
| Product | HCID 24998228 | HCID 24998228 | — |
Reaction Steps
The starting material can be prepared from the compound of Reference Example 297, [2-(4-bromo-phenyl)-indolizin-3-yl]-oxo-acetyl chloride, and aniline. Step 1 describes a Buchwald reaction, e.g. with N-methylpiperazine, bis(triphenylphosphine) palladium(II) dichloride, cesium carbonate and DMF/toluene at 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08604029B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-3cd11c36e6a44ad081967ce61e4d2f60 |
| Source note | uspto-grants-2013_12 |