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0 °C

Manganese dioxide (3.17 g, 36.5 mmol) was added to a solution of (4,6-dimethyl-pyridin-2-yl)-methanol (1.0 g, 7.30 mmol) in chloroform (30 mL) and heated at reflux overnight. The reaction mixture was cooled to 0° C. and filtered over celite, washing with further chloroform. The filtrate was evaporated to give a residue which was purified by column chromatography over silica gel (60-120 mesh) using 10% ethyl acetate in hexane as eluent to afford 4,6-dimethyl-pyridine-2-carbaldehyde (0.5 g, 51%) as a light brown liquid.

1. temperatureheated
2. temperatureat reflux overnight
3. filtrationfiltered over celite
4. washwashing with further chloroform
5. customThe filtrate was evaporated
6. customto give a residue which
7. customwas purified by column chromatography over silica gel (60-120 mesh)