1-Chloro-4-nitrobenzene → 4-(4-Nitrophenyl)thiomorpholine

Participants

Reaction Steps

A solution of 1-chloro-4-nitrobenzene (1.5 g, 9.5 mmol) and thiomorpholine (1.0 g, 9.7 mmol) in n-butanol was heated at reflux for 24 h. The solvent was evaporated under reduced pressure to give a residue, which on trituration with water gave a solid. This was filtered off and washed thoroughly with water then with a small amount of petroleum ether. This gave a solid which was recrystallised from ethanol to yield 4-(4-nitro-phenyl)-thiomorpholine (1.6 g, 76%).

Provenance & Evidence