反应详情

温度

60 °C

Zinc powder (0.47 g, 7.2 mmol) was added to a solution of 4-(4-nitro-phenyl)-thiomorpholine 1,1-dioxide (155 mg, 0.60 mmol) in acetic acid (3 mL) and the mixture was stirred at 60° C. for 2 h. The reaction mixture was concentrated to dryness, diluted with ethyl acetate and washed with sodium bicarbonate solution and water then dried over sodium sulfate. The organic layer was concentrated to dryness to afford 4-(1,1-dioxo-1λ6-thiomorpholin-4-yl)-phenylamine (70 mg, 51%).

1. concentrationThe reaction mixture was concentrated to dryness
2. additiondiluted with ethyl acetate
3. washwashed with sodium bicarbonate solution and water
4. dry with materialthen dried over sodium sulfate
5. concentrationThe organic layer was concentrated to dryness