HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Nitrophenyl)piperidin-4-one → 1-(4-Aminophenyl)piperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Nitrophenyl)piperidin-4-one | HCID 3842562 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Aminophenyl)piperidin-4-one | HCID 22220241 | 90.5% |
Reaction Steps
A solution of 1-(4-nitrophenyl)-4-piperidone (400 mg, 1.8 mmol) in methanol (5 μL) was hydrogenated over Raney nickel (0.08 g) at atmospheric pressure for 3 hours at r.t. The mixture was filtered through Celite and the filtrate evaporated to dryness to obtain 1-(4-aminophenyl)-4-piperidone (310 mg, 89%) as a semisolid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08604029B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-4bcb3fe331174c9abecf3fb28b7c6882 |
| Source note | uspto-grants-2013_12 |