HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 2-Phenylindolizine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Methyl-1-(2-oxo-2-phenylethyl)pyridinium bromide | HCID 12316824 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Phenylindolizine | HCID 96128 | 70% |
Reaction Steps
A solution of sodium hydrogen carbonate (10.5 g, 120 mmol) in water (125 mL) was added to 2-methyl-1-(2-oxo-2-phenyl-ethyl)-pyridinium bromide (35.0 g, 120 mmol) and the reaction heated to reflux for 30 min. The resultant solid was filtered, washed with water and then dried under vacuum to yield 2-phenyl-indolizine (16.0 g, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08604029B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-36d9017c3c1247c9948f57064f0194b8 |
| Source note | uspto-grants-2013_12 |