2-Chloropyridine → N-(2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-yl)pyridin-2-amine

Participants

Reaction Steps

According to Scheme 1 Step 9: A solution of 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-amine (0.70 mmol, 200 mg), 2-chloropyridine (0.70 mmol, 65.6 μL), CyPF-tBu (52 μmol, 29.4 mg), Pd(OAc)2 (52 μmol, 11.8 mg) and sodium tert-butoxide (0.98 mmol, 71.4 mg) in DME (698 μL) was stirred at 80° C. for 12 hours under nitrogen in a microwave tube. After filtration through celite, the resulting crude product was purified by flash chromatography over silica gel using DCM/EtOH/NH3 (100:0:0 to 95:4.5:0.5) as eluent to afford N-(2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-yl)pyridin-2-amine (0.39 mmol, 144 mg, 57%).

Provenance & Evidence