HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1910878Generated: November 2, 2026
Hydrochloric Acid → HCID 178508813, compound
https://huagongshe.com/reaction/1910878
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-methoxy-5-(trifluoromethyl)-4-Pyrimidinamine | HCID 66607644 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178508813 | HCID 178508813 | — |
Reaction Steps
To a solution of 6-methoxy-5-(trifluoromethyl)pyrimidin-4-amine (N-3) (420 mg, 2.18 mmol) in 1,4-dioxane (10 mL), concentrated HCl (1.81 mL, 21.8 mmol) is added and the resulting mixture is stirred at 90° C. for 3 h. The mixture is allowed to cool to RT and then concentrated in vacuo to afford the product, 6-amino-5-(trifluoromethyl)pyrimidin-4-ol (N-4) as yellowish solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08604032B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-ddd57bfceb00419393638a34c3f94750 |
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| Source note | uspto-grants-2013_12 |
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