Ethanol → Ethyl 6-[1-(tert-butoxycarbonyl)piperidin-4-yl]pyridine-2-carboxylate

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Reaction Steps

1′-tert-Butyl 6-ethyl-3′,6′-dihydro-2,4′-bipyridine-1′,6(2′H)-dicarboxylate (31.5 g) is dissolved in ethanol (315 ml) and hydrogenated at room temperature under 1 bar of H2 in the presence of Pd/C (10%, 4.5 g) for 12 hours. Filtration and removal of the solvent under reduced pressure gives ethyl 6-[1-(tert-butoxycarbonyl)piperidin-4-yl]pyridine-2-carboxylate (30.5 g).

Provenance & Evidence