HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1910982Generated: October 31, 2026
Hydrochloric Acid → 4-[6-(Ethoxycarbonyl)pyridin-2-yl]piperidinium chloride
https://huagongshe.com/reaction/1910982
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 6-[1-(tert-butoxycarbonyl)piperidin-4-yl]pyridine-2-carboxylate | HCID 66686619 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[6-(Ethoxycarbonyl)pyridin-2-yl]piperidinium chloride | HCID 66687951 | — |
Reaction Steps
To a solution of ethyl 6-[1-(tert-butoxycarbonyl)piperidin-4-yl]pyridine-2-carboxylate (2.0 g) was added dropwise, at 0° C., a 4 molar solution of hydrochloric acid in 1,4-dioxane (45 ml). The reaction mixture was stirred at 0° C. and then gradually warmed to room temperature. After stirring overnight, the solvent and excess hydrogen chloride were removed. This gave 4-[6-(ethoxycarbonyl)pyridin-2-yl]piperidinium chloride (1.75 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08604040B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-fe8edfaaa3fa473ca1090ead4e5fe9c0 |
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| Source note | uspto-grants-2013_12 |
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