Methanol → HCID 67086052, compound

Participants

Reaction Conditions

Reaction Steps

To solution of 5-hydroxypicolinic acid (820 mg, 5.89 mmol) in methanol (20 mL) was dropwise added thionyl chloride (0.430 mL, 5.89 mmol) at rt. The mixture was stirred at 60° C. for 20 h. The mixture was concentrated in vacuo to give a crude methyl 5-hydroxypicolinate hydrochloride (1.12 g, 5.89 mmol, 100% yield), which was used for the next step without purification. LCMS (M+H)+=154.01. 1H NMR (500 HMz, methanol-d4) δ 8.45 (d, J=6.0 Hz, 2H), 8.08 (dd, J=9.0, 2.3 Hz, 1H), 4.09 (s, 3H)

Provenance & Evidence