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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1911047Generated: October 30, 2026

Ethyl 6-bromohexanoate → HCID 86622380, compound

https://huagongshe.com/reaction/1911047

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 6-bromohexanoateHCID 117544—
Reactant2-[[4-[(3-Chloro-4-fluorophenyl)amino]-6-quinazolinyl]oxy]-N-hydroxyacetamideHCID 24945021—
ReactantHCID 86622381HCID 86622381—
ProductHCID 86622378HCID 86622378—
ProductHCID 86622380HCID 8662238064%

Reaction Steps

The title compound ethyl 6-(4-(3-ethynylphenylamino)quinazolin-6-yloxy)hexanoate (0212-23) (0.3 g, 64%) was prepared from compound 4-(3-ethynylphenylamino)quinazolin-6-ol (0211) and ethyl 6-bromohexanoate using a procedure similar to that described for compound 0210-13 (Example 9): LC-MS m/z 404 [M+1].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08604044B2
Source datasetuspto-grants-2013_12
ORD IDord-7c3106b8e8b843a186e9234be815db0a
Source noteuspto-grants-2013_12