Hydrochloric Acid → HCID 178421629, compound

Participants

Reaction Conditions

Reaction Steps

In a 5 ml sealed tube, a mixture of 1-chloro-9-methoxy-5-methyl-6H-pyrido[4,3-b]carbazole (75 mg, 0.25 mMol) (prepared according to J. Chem. Soc. Perkin Trans. 1, 1979, 1706), benzyltriethylammonium chloride (225 mg, 1 mMol) and 37% hydrochloric acid (4 ml) is heated in an oil bath at 140° C. for 24 h. The reaction mixture is then evaporated, under vacuum, then 20 ml of water are added. The medium is then rendered basic by addition of 28% ammonium hydroxide (0.5 ml), and the solid is recovered by low-temperature filtration, then washed with water and dried using a vacuum desiccator, at a temperature of 200° C. for 18 h. 65 mg (90% yield) of Compound 10 are then obtained, the proton NMR spectrum of which is the following:

Provenance & Evidence