HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 178422579, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Cyclohexane-1,1-diol | HCID 19352763 | — |
| Reactant | 5-Chloro-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine | HCID 44632882 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 178422579 | HCID 178422579 | — |
Reaction Steps
200 mg (1.7 mmol) cyclohexanediol was placed in 1.5 ml dimethylacetamide and 47 mg (1.17 mmol) sodium hydride (60%) were added and the mixture was stirred for 15 min at ambient temperature. Then 100 mg (0.31 mmol) 6.1 was added and the mixture was stirred for 2 h at 70° C. The reaction mixture was diluted with dichloromethane and extracted 1× with water. The organic phase was dried with MgSO4 and evaporated down. The residue was purified by chromatography (RP-HPLC-MS). The corresponding fractions were freeze-dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08604049B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-93609c1e40ba4922aaeff9618f212350 |
| Source note | uspto-grants-2013_12 |