HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-Fluorophenyl)benzoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-(4-fluorophenyl)benzoxazole-4-carboxylate | HCID 59626027 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(4-Fluorophenyl)benzoxazole-4-carboxylic acid | HCID 59626030 | 80.7% |
Reaction Steps
A mixture of 1.1 g (4.0 mmol) methyl 2-(4-fluorophenyl)benzo[d]oxazole-4-carboxylate 9ee and 3.7 mL of 3N aqueous NaOH in 10 mL of THF was refluxed overnight. After cooling the reaction mixture was poured into water and acidified with conc. HCl. The resulting solid was filtered and dried to give 830 mg (79%) of 2-(4-fluorophenyl)-benzo[d]oxazole-4-carboxylic acid, 9ff. MS m/z (M+H+) 258.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08604017B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-dd6bb7fb1d90412f9d6fa9356bf2cba3 |
| Source note | uspto-grants-2013_12 |