HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Fluoro-5-phenyl-benzo[b]thiophene-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-Fluoro-5-phenyl-benzo[b]thiophene-2-carboxylic acid | HCID 59625825 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Fluoro-5-phenyl-benzo[b]thiophene-2-carbonyl chloride | HCID 59625725 | — |
Reaction Steps
To a solution of compound 52d (136.2 mg, 0.5 mmol) in CH2Cl2 (5 mL) at room temperature was added (COCl)2 (0.064 mL, 0.75 mmol), followed by DMF (0.01 mL, 0.125 mmol). The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was then concentrated to give compound 52e (light pink powder), which was used in the next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08604017B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-a62458b77e3140ddbf2ce6924509515d |
| Source note | uspto-grants-2013_12 |