HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1911203Generated: November 1, 2026
Potassium Phosphate, Tribasic → HCID 59625710, compound
https://huagongshe.com/reaction/1911203
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Methyl 3-chloro-6-fluoro-1-benzothiophene-2-carboxylate | HCID 762658 | — |
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | HCID 11269872 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59625710 | HCID 59625710 | — |
Reaction Steps
A mixture of methyl 3-chloro-6-fluorobenzo[b]thiophene-2-carboxylate 65a (0.613 mmol, 150 mg), cyclopropylboronic acid 65b (0.92 mmol, 79 mg), Pd(OAc)2 (0.09 mmol, 20 mg), SPhos (0.215 mmol, 88 mg), and K3PO4 (1.23 mmol, 0.26 g) in toluene (2 mL) was heated to 100° C. for 3 h in a sealed reaction vessel. The reaction was diluted with EtOAc and water. The organic layer was concentrated and purified by flash column chromatography (silica gel, 10% EtOAc/hexanes) to give compound 65c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08604017B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-b7566f2b06ea48c29423c3239d5e8e84 |
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| Source note | uspto-grants-2013_12 |
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