5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid → HCID 178432274, compound

HRID 1911243Notes

Reaction equation

HRID 1911243 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=1)[C:6]([C:19]([OH:21])=O)=[CH:5]2.[NH2:22][C:23]1[CH:24]=[C:25]2[N:31]=[C:30]([CH3:32])[NH:29][C:26]2=[N:27][CH:28]=1>>[CH3:32][C:30]1[NH:29][C:26]2=[N:27][CH:28]=[C:23]([NH:22][C:19]([C:6]3[N:7]([CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=4)[C:8]4[C:4]([CH:5]=3)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=4)=[O:21])[CH:24]=[C:25]2[N:31]=1

Participants

3

Reactant 2

HCID 574315135-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acidHCID 178432272HCID 178432272, compound

Product 1

HCID 178432274HCID 178432274, compound

Procedure

This compound was prepared according to a process similar to that described in Example 1.2, starting with 5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylic acid, prepared in Example 1.1 and 6-amino-2-methyl-3H-imidazo[4,5-b]pyridine, prepared in the preceding step.

Workup

  1. customThis compound was prepared
  2. customprepared in the preceding step

Sources & evidence

ORD record
ord-1c415c541f0349de95a68221ed236dc9
Source dataset
uspto-grants-2013_12
Patent number
US08604050B2

Reaction notes

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