Trimethylaluminum → HCID 66888773, compound

Participants

Reaction Steps

This compound was prepared according to a process similar to that described in step 16.2, by reacting 200 mg (0.523 mmol) of ethyl 6-trimethylsilyl-1-[(thiazol-2-yl)]methyl-1H-indole-2-carboxylate, prepared in the preceding step, with 178 mg (0.670 mmol) of (6-amino-thiazolo[5,4-b]pyrid-2-yl)methyl 2,2-dimethylpropanoate, obtained in step 4.2, in the presence of 0.39 mL (0.784 mmol) of a solution of trimethylaluminium (2M/toluene). The product was isolated by purification by chromatography on a column of silica, eluting with a mixture of dichloromethane and ethanol. 120 mg of the expected product are obtained.

Provenance & Evidence