Acetone → 2,2-Dimethyl-chroman-4-one

HRID 1911268Notes

Reaction equation

HRID 1911268 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.N.[CH3:13][C:14](=O)[CH3:15]>>[CH3:13][C:14]1([CH3:15])[CH2:9][C:8](=[O:10])[C:6]2[C:5](=[CH:4][CH:3]=[CH:2][CH:7]=2)[O:11]1

Participants

4

Reactant 3

HCID 180AcetoneHCID 222AmmoniaHCID 959922-Acetyl-4-fluorophenol

Product 1

HCID 74542902,2-Dimethyl-chroman-4-one

Procedure

The title compound was prepared according to the procedure of Example 1A, substituting 1-(2-hydroxyphenyl)ethanone for 1-(5-fluoro-2-hydroxyphenyl)ethanone and using propan-2-one. MS (DCI/NH3) m/z 194 (M+NH4)+.

Sources & evidence

ORD record
ord-d7d3d2bd8edc44409b170c1afc4b69f6
Source dataset
uspto-grants-2013_12
Patent number
US08604053B2

Reaction notes

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