HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid | HCID 2394006 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride | HCID 12047330 | — |
Reaction Steps
A reaction vessel is charged with toluene, a catalytic amount of DMF (1-5% by weight of the amount of thionyl chloride employed) and 1 equivalent of 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid. While stirring, 1 to 4 equivalents of thionyl chloride are slowly added at 70 to 90° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08604064B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-826aec603f994e83a291f04ba6e39403 |
| Source note | uspto-grants-2013_12 |