4-Chlorophenylboronic acid → HCID 59323859, compound

HRID 1911503Notes

Reaction equation

HRID 1911503 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][O:11][C:10]([NH2:13])=[N:9]2)=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]3[CH2:12][O:11][C:10]([NH2:13])=[N:9]3)=[CH:4][CH:3]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 59323892HCID 59323892, compound

Product 1

HCID 59323859HCID 59323859, compound

Procedure

In analogy to example 30, (RS)-4-(4-bromo-phenyl)-4,5-dihydro-oxazol-2-ylamine was reacted with 4-chlorophenylboronic acid to give (RS)-4-(4′-chloro-biphenyl-4-yl)-4,5-dihydro-oxazol-2-ylamine. Off-white solid. MS (ISP): 273.1 ([M+H]+)

Sources & evidence

ORD record
ord-36601bc3d99841559a812f7f9331c64c
Source dataset
uspto-grants-2013_12
Patent number
US08604061B2

Reaction notes

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