Cyanogen Bromide → HCID 59323819, compound

HRID 1911511Notes

Reaction equation

HRID 1911511 reaction equation
[NH2:1][C@H:2]([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[CH2:3][OH:4].[N:14]#[C:15]Br>>[F:13][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][C@@H:2]2[CH2:3][O:4][C:15]([NH2:14])=[N:1]2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 68714455HCID 68714455, compound

Product 1

HCID 59323819HCID 59323819, compound

Procedure

In analogy to example 1b (R)-2-amino-4-(4-fluoro-phenyl)-butan-1-ol was reacted with cyanogen bromide to give (R)-4-[2-(4-fluoro-phenyl)-ethyl]-4,5-dihydro-oxazol-2-ylamine. White solid. MS (ISP): 209.3 ([M+H]+))

Sources & evidence

ORD record
ord-774b43f30fb644d98fb83dfec97b931f
Source dataset
uspto-grants-2013_12
Patent number
US08604061B2

Reaction notes

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