Cyanogen Bromide → HCID 59323735, compound

HRID 1911514Notes

Reaction equation

HRID 1911514 reaction equation
[NH2:1][C@H:2]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][OH:4].[N:13]#[C:14]Br>>[O:6]([CH2:5][C@@H:2]1[CH2:3][O:4][C:14]([NH2:13])=[N:1]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 16106975HCID 16106975, compound

Product 1

HCID 59323735HCID 59323735, compound

Procedure

In analogy to example 1b (S)-2-amino-3-phenoxy-propan-1-ol was reacted with cyanogen bromide to give (R)-4-phenoxymethyl-4,5-dihydro-oxazol-2-ylamine. Colourless gum. MS (ISP): 193.1 ([M+H]+))

Sources & evidence

ORD record
ord-444857540f6f4a14b420041015fe7321
Source dataset
uspto-grants-2013_12
Patent number
US08604061B2

Reaction notes

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