Cyanogen Bromide → HCID 24968263, compound

HRID 1911536Notes

Reaction equation

HRID 1911536 reaction equation
[NH2:1][C@@H:2]([CH2:5][CH:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:7][CH3:8])[CH2:3][OH:4].[N:15]#[C:16]Br>>[C:9]1([CH:6]([CH2:7][CH3:8])[CH2:5][C@H:2]2[CH2:3][O:4][C:16]([NH2:15])=[N:1]2)[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 68716614HCID 68716614, compound

Product 1

HCID 24968263HCID 24968263, compound

Procedure

In analogy to example 1b (S)-2-amino-4-phenyl-hexan-1-ol was reacted with cyanogen bromide to give (S)-4-(2-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine (mainly one epimer). White crystalline solid. MS (ISP): 219.4 ([M+H]+).

Sources & evidence

ORD record
ord-a85a4570a8894856a952f709408c6bb3
Source dataset
uspto-grants-2013_12
Patent number
US08604061B2

Reaction notes

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