Cyanogen Bromide → HCID 24963281, compound

HRID 1911556Notes

Reaction equation

HRID 1911556 reaction equation
[NH2:1][C@@H:2]([CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=1)[CH2:3][OH:4].[N:14]#[C:15]Br>>[Cl:13][C:9]1[CH:8]=[C:7]([CH2:6][CH2:5][C@H:2]2[CH2:3][O:4][C:15]([NH2:14])=[N:1]2)[CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 68715316HCID 68715316, compound

Product 1

HCID 24963281HCID 24963281, compound

Procedure

In analogy to example 1b (S)-2-amino-4-(3-chloro-phenyl)-butan-1-ol was reacted with cyanogen bromide to give (S)-4-[2-(3-chloro-phenyl)-ethyl]-4,5-dihydro-oxazol-2-ylamine. Light yellow viscous oil. MS (ISP): 227.2 ([{37Cl}M+H]+), 225.1 ([{35Cl}M+H]+).

Sources & evidence

ORD record
ord-1412e66fa4b346fa822228c2573462ab
Source dataset
uspto-grants-2013_12
Patent number
US08604061B2

Reaction notes

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