HCID 65585094, compound → HCID 59323842, compound

HRID 1911558Notes

Reaction equation

HRID 1911558 reaction equation
[CH3:1][C:2]1([C:8]2[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][CH:9]=2)[CH2:6][O:5][C:4]([NH2:7])=[N:3]1>CCO.CCCCCCC>[CH3:1][C@:2]1([C:8]2[CH:9]=[CH:10][C:11]([O:14][C:15]([F:18])([F:16])[F:17])=[CH:12][CH:13]=2)[CH2:6][O:5][C:4]([NH2:7])=[N:3]1

Participants

3

Reactant 1

HCID 65585094HCID 65585094, compound

Product 1

HCID 59323842HCID 59323842, compound

Reagents, catalysts & solvents 1

HCID 22502148Ethanol heptaneSolvent

Procedure

((RS)-4-Methyl-4-(4-trifluoromethoxy-phenyl)-4,5-dihydro-oxazol-2-ylamine was sepa-rated by chiral HPLC (Chiralpak AD, EtOH/heptane 10:90) to give (S)-4-methyl-4-(4-trifluoromethoxy-phenyl)-4,5-dihydro-oxazol-2-ylamine. (+)-Enantiomer. Viscous colorless oil.

Sources & evidence

ORD record
ord-6d1b3dd48bcd4fbd8480a27f5a52ea99
Source dataset
uspto-grants-2013_12
Patent number
US08604061B2

Reaction notes

Loading…