HCID 68711632, compound → HCID 59323715, compound

HRID 1911560Notes

Reaction equation

HRID 1911560 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH3:15])[CH2:13][O:12][C:11]([NH2:14])=[N:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1>CCO.CCCCCCC>[Cl:1][C:2]1[CH:3]=[C:4]([C@@:9]2([CH3:15])[CH2:13][O:12][C:11]([NH2:14])=[N:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 1

HCID 68711632HCID 68711632, compound

Product 1

HCID 59323715HCID 59323715, compound

Reagents, catalysts & solvents 1

HCID 22502148Ethanol heptaneSolvent

Procedure

(RS)-4-(3-Chloro-5-fluoro-phenyl)-4-methyl-4,5-dihydro-oxazol-2-ylamine was sepa-rated by chiral HPLC (Chiralpak AD, EtOH/heptane 15:850) to give (S)-4-(3-chloro-5-fluoro-phenyl)-4-methyl-4,5-dihydro-oxazol-2-ylamine. (+)-Enantiomer. White solid.

Sources & evidence

ORD record
ord-56872c53ec204fb19815860b80d8ec2a
Source dataset
uspto-grants-2013_12
Patent number
US08604061B2

Reaction notes

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