Water → HCID 86657603, compound

Participants

Reaction Steps

At room temperature, 2.3 g (0.06 mol) of lithium aluminohydride in 100 ml of absolute diethyl ether in a three-neck flask equipped with stirrer, dropping funnel and high-performance condenser are, while continuously stirring, admixed with a solution of 22.0 g (0.1 mol) of butyl ethyl(2-methyl-2-formylethyl)phosphinate in 100 ml of diethyl ether added dropwise at such a rate that there is a moderate boil of the diethyl ether. On completion of the dropwise addition the reaction solution is refluxed for 1 hour and subsequently admixed with 1.8 g (0.1 mol) of water. The insoluble salts are filtered off. The solvent of the filtrate is removed in vacuo and the product is purified by chromatography to obtain 18.9 g (85% of theory) of butyl ethyl(2-methyl-3-hydroxypropyl)phosphinate as colorless oil.

Provenance & Evidence