Water → HCID 46901656, compound

HRID 1911720Notes

Reaction equation

HRID 1911720 reaction equation
[CH2:1]([P:3]([CH2:10][CH:11]([CH3:14])[CH2:12][OH:13])(=[O:9])[O:4]CCCC)[CH3:2].O>C(O)CCC.O>[CH2:1]([P:3]([CH2:10][CH:11]([CH3:14])[CH2:12][OH:13])(=[O:4])[OH:9])[CH3:2]

Participants

4

Reactant 2

HCID 962WaterHCID 86657603HCID 86657603, compound

Product 1

HCID 46901656HCID 46901656, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 22253497Water butanolSolvent

Procedure

444 g (2 mol) of butyl ethyl(2-methyl-3-hydroxypropyl)phosphinate (produced as in Example 13) are initially charged to a 1 l five-neck flask equipped with thermometer, reflux condenser, high-performance stirrer and dropping funnel. At 160° C., during 4 h, 500 ml of water are metered in and a butanol-water mixture is distilled off. The solid residue is recrystallized from acetone to obtain 329 g (99% of theory) of ethyl(2-methyl-3-hydroxypropyl)phosphinic acid as oil.

Workup

  1. customequipped with thermometer
  2. temperaturereflux condenser, high-performance stirrer
  3. distillationis distilled off
  4. customThe solid residue is recrystallized from acetone

Sources & evidence

ORD record
ord-673a392eae9247d6aa26432832c02708
Source dataset
uspto-grants-2013_12
Patent number
US08604108B2

Reaction notes

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