Sodium Hydroxide → HCID 86610068, compound

HRID 1911787Notes

Reaction equation

HRID 1911787 reaction equation
C(O[C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[CH2:15][N:16]([CH2:23][C:24]1[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([C:34]([F:37])([F:36])[F:35])[CH:25]=1)[C:17]1[N:18]=[N:19][N:20]([CH3:22])[N:21]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])C.[OH-].[Na+]>C(O)C>[CH2:6]([N:7]([CH2:8][CH3:9])[C:4]([C:6]1[CH:14]([CH2:15][N:16]([CH2:23][C:24]2[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([C:34]([F:35])([F:37])[F:36])[CH:25]=2)[C:17]2[N:18]=[N:19][N:20]([CH3:22])[N:21]=2)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1)=[O:5])[CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23729292HCID 23729292, compound

Product 1

HCID 86610068HCID 86610068, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To the solution of 3-{[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-methyl}-1H-indole-2-carboxylic acid ethyl ester (0.2 g, 0.38 mmol) in 5 mL ethanol, was added NaOH (0.076 g, 1.9 mmol). The reaction was refluxed under nitrogen atm for 1 h. The reaction mixture was acidified and the suspension was filtered to afford the title compound (0.1 g, 53%)

Workup

  1. temperatureThe reaction was refluxed under nitrogen atm for 1 h
  2. filtrationthe suspension was filtered

Sources & evidence

ORD record
ord-869c9770916c4649b03041d3bb04bca7
Source dataset
uspto-grants-2013_12
Patent number
US08604055B2

Reaction notes

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