2-Bromotoluene → HCID 11695190, compound

Participants

Reaction Steps

The title compound was prepared from commercially available ethyl isonipecotate, o-tolyl bromide as the aryl halide, and thiomorpholine as the secondary amine utilizing general procedures A and B described above. 1H NMR (300 MHz, CDCl3) δ 7.19-7.13 (m, 2H), 7.00-6.95 (m, 2H), 3.95 (m, 2H), 3.82 (m, 2H), 3.21 (m, 1H), 3.17 (m, 1H), 2.71-2.54 (m, 7H), 2.30 (s, 3H), 2.09 (dd, J=3.6, 13.1 Hz, 1H), 2.00 (dd, J=3.6, 12.0 Hz, 1H), 1.79 (m, 1H), 1.75 (m, 1H). ESI MS: 305.3 (MH+).

Provenance & Evidence