3-Bromo-o-xylene → HCID 11645379, compound

Participants

Reaction Steps

The title compound was prepared from commercially available ethyl isonipecotate, 2,3-dimethylbromobenzene as the aryl halide, and 4-hydroxypiperidine as the secondary amine utilizing general procedures A and B described above. 1H NMR (300 MHz, CDCl3) δ 7.06 (d, J=7.7 Hz, 1H), 6.90 (d, J=7.7 Hz, 2H), 4.12 (m, 1H), 3.96 (m, 1H), 3.83 (m, 1H), 3.33-3.13 (m, 4H), 2.70-2.61 (m, 3H), 2.27 (s, 3H), 2.22 (s, 3H), 2.12-1.43 (m, 8 H). ESI MS: 317.4 (MH+).

Provenance & Evidence