Thiomorpholine → HCID 11688302, compound

Participants

Reaction Steps

The title compound was prepared from commercially available ethyl isonipecotate, 3,4-dimethylbromobenzene as the aryl halide, and thiomorpholine as the secondary amine utilizing general procedures A and B described above. 1H NMR (300 MHz, CDCl3) 1H NMR (CDCl3) δ 7.01 (d, J=7.8 Hz, 1H), 6.76 (d, J=2.3 Hz, 1H), 6.70 (dd, J=2.3, 7.8 Hz, 1H), 3.90 (m, 2H), 3.80 (m, 2H), 2.96 (m, 1H), 2.89 (m, 1H), 2.71-2.50 (m, 7H), 2.23 (s, 3H), 2.18 (s, 3H), 2.04 (dd, J=2.6, 12.2 Hz, 1H), 1.93 (dd, J=3.3, 12.3 Hz, 1H), 1.80 (m, 1H), 1.76 (m, 1H). ESI MS: 319.4 (MH+).

Provenance & Evidence