反应详情

温度

60 °C

Ethanol (25 mL) was added to a reaction vessel containing sorafenib free base (5 g). The reaction mixture was stirred for about 5 minutes. Temperature was raised to about 60° C. The reaction mixture was stirred for about 30 minutes. Sulphuric acid solution (sulphuric acid: ethanol: water: 0.57 mL: 6 mL: 19 mL) was added drop wise. The reaction mixture was cooled to room temperature and stirred for about 12 hours. The reaction mixture was concentrated. The solid was filtered and dried under reduced pressure at about 50° C. for about 12 hours to obtain sorafenib sulphate.

1. stirringThe reaction mixture was stirred for about 30 minutes
2. temperatureThe reaction mixture was cooled to room temperature
3. stirringstirred for about 12 hours
4. concentrationThe reaction mixture was concentrated
5. filtrationThe solid was filtered
6. customdried under reduced pressure at about 50° C. for about 12 hours