5-Aminoisoquinoline → N-(Pyrrolidin-3-yl)isoquinolin-5-amine

HRID 1911886Notes

Reaction equation

HRID 1911886 reaction equation
O=[C:2]1[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[CH:14]1[C:23]2[CH:22]=[CH:21][CH:20]=[C:19]([NH2:24])[C:18]=2[CH:17]=[CH:16][N:15]=1>>[NH:4]1[CH2:5][CH2:6][CH:2]([NH:24][C:19]2[C:18]3[CH:17]=[CH:16][N:15]=[CH:14][C:23]=3[CH:22]=[CH:21][CH:20]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 707665-AminoisoquinolineHCID 471360Tert-butyl 3-oxopyrrolidine-1-carboxylate

Product 1

HCID 57936477N-(Pyrrolidin-3-yl)isoquinolin-5-amine

Procedure

Reaction of tert-butyl 3-oxopyrrolidine-1-carboxylate and isoquinolin-5-amine using the method of Example 3 followed by deprotection using the method of Example 4 afforded the title compound.

Sources & evidence

ORD record
ord-a29b299ca3c34e209adf9bb8517029af
Source dataset
uspto-grants-2013_12
Patent number
US08604205B2

Reaction notes

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