5-Bromoisoquinoline → HCID 59799791, compound

HRID 1911895Notes

Reaction equation

C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([NH2:13])[CH2:9]1)=O)(C)(C)C.Br[C:15]1[CH:24]=[CH:23][CH:22]=[C:21]2[C:16]=1[CH:17]=[CH:18][N:19]=[CH:20]2>>[NH:8]1[CH2:12][CH2:11][C@H:10]([NH:13][C:15]2[C:16]3[CH:17]=[CH:18][N:19]=[CH:20][C:21]=3[CH:22]=[CH:23][CH:24]=2)[CH2:9]1

Participants

Reactant 2

HCID 7364875-Bromoisoquinoline

HCID 854071tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate

Product 1

HCID 59799791HCID 59799791, compound

Procedure

Reaction of (S)-tert-butyl3-aminopyrrolidine-1-carboxylate and 5-bromoisoquinoline using the method of Example 16 followed by deprotection using the method of Example 4 afforded the title compound.

Sources & evidence

ORD record: ord-cbe7e1f9bc6b44e3befb41201ca74aaa
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08604205B2

Reaction notes

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