Triethylamine → HCID 68193679, compound

Participants

Reaction Steps

3-(4-iodophenyl)-1-(pyridin-2-yl)-1H-pyrazol-5-ol (0.5 mmol, 1 equivalent) was dissolved in CH2Cl2 (5 mL) to which 3 equivalents of triethylamine were then added. Under stream of nitrogen, 2 equivalents of triisopropylsilyl chloride (TIPSCl) were added thereto at 0° C., followed by stirring at room temperature. After 10 minutes, the solution was concentrated by distillation under reduced pressure and hexane was added thereto, followed by washing with a saturated NaHCO3 aqueous solution. After extraction with hexane twice, the organic layer was dried over anhydrous MgSO4, filtered, concentrated and then dried under vacuum to afford the title compound.

Provenance & Evidence