HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → 6-fluoro-4-oxo-4H-chromene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | 2-Acetyl-4-fluorophenol | HCID 95992 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Product | 6-fluoro-4-oxo-4H-chromene-2-carboxylic acid | HCID 4096046 | — |
Reaction Steps
5-Fluoro-2-hydroxyacetophenone (II) was treated with potassium tertiary butoxide and diethyl oxalate to give 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid (III) according to Reaction 1 as given below by a known process (JP 2218675).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08604222B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-7ca5c044dee446d28654d3f122d3973f |
| Source note | uspto-grants-2013_12 |