5-Aminoisoquinoline → HCID 59799771, compound

HRID 1911993Notes

Reaction equation

HRID 1911993 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[CH:15]1[C:24]2[CH:23]=[CH:22][CH:21]=[C:20]([NH2:25])[C:19]=2[CH:18]=[CH:17][N:16]=1>>[NH:4]1[CH2:5][CH2:6][CH2:7][CH:2]([NH:25][C:20]2[C:19]3[CH:18]=[CH:17][N:16]=[CH:15][C:24]=3[CH:23]=[CH:22][CH:21]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 707665-AminoisoquinolineHCID 2756825Tert-butyl 3-oxopiperidine-1-carboxylate

Product 1

HCID 59799771HCID 59799771, compound

Procedure

Reaction of tert-butyl 3-oxopiperidine-1-carboxylate and isoquinolin-5-amine using the method of Example 3 followed by deprotection using the method of Example 4 afforded the title compound.

Sources & evidence

ORD record
ord-7cd181cb1927491b9840523cd669eca3
Source dataset
uspto-grants-2013_12
Patent number
US08604218B2

Reaction notes

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